Neurofisiología Integrativa

Responsable del Laboratorio de Neurofisiología Integrativa

Instituto de Fisiología
Benemerita Universidad Autonoma de Puebla
14 Sur 6301, Col San Manuel, Puebla, Pue., Mexico
Tels. +5222 22 295500 Ext 7326
Fax. +5222 22 295500 Ext 7323

eliasmanjarrez@gmail.com
elias.manjarrez@correo.buap.mx

SNI, nivel III



CURRENT POSITION

Professor of Neurophysiology, Institute of Physiology,  Benemerita Universidad Autonoma de Puebla, Puebla, Mexico (2000  -      ).


EDUCATION

Invited Professor at the Neurological Clinic, University of Freiburg, 2012

  • Ph.D. in Neuroscience.  Center for Research and Advanced Studies (CINVESTAV), National Polytechnic Institute, Mexico (1993-2000) 

  • M.S.  in Physiological Sciences, Benemerita Universidad Autonoma de Puebla (1990-1993)

  • B.S..  in Physics, Benemerita Universidad Autonoma de Puebla  (1984-1989)



EMPLOYMENT

  • Professor, research and  teaching. Laboratory head, Integrative Neurophysiology Lab, Institute of Physiology,  Benémerita Universidad Autonóma de Puebla. Puebla, México. (2000-     )

  • Guest Professor, Freiburg University, Germany

  • Research: Functional organization of neuronal ensembles in the CNS of humans and cats, Stochastic Resonance in the CNS, Electrical Traveling Waves in the CNS.

  • Teaching:  Neurophysiology, Bioelectricity, Neuroanatomy,  Physics , Institute of Physiology  (2000-   )

  • Teaching:  Statistics, Medicine School, Benemerita Universidad Autonoma de Puebla (1993)

  • Teaching:  Physics and Mathematics, Mathematics Department, Universidad de las Américas-Puebla, UDLA. (1989 -1992)


HONORS
  • Proyecto Fronteras de la Ciencia 2016-2018

  • Cátedra Marcos Moshinsky 2012-2014

  • Acknowledgement  by  CONACyT  “proyectos, casos de éxito” 2012.

  • Member of the Mexican Academy of Science committee for the National Prize of young researchers 2012-2015

  • Prize CONACyT at statal Level, Medical Science area, 2010

  • Member of the Mexican Academy of Sciences

  • Member of the National System of Research (SNI 2, Mexico)

  • Weizmann Prize, Mexican Academy of Sciences (2005)

  • Graduated with honorific mention, B.S. in Physics (July 1989)

  • Graduated with honorific mention, M.S in Physiological Sciences (December 1993)

  • Graduated with honorific mention, PhD in Neuroscience (July 2000)

RESEARCH SUPPORT (GRANTS)

  • Grant CONACyT: 253164-Ciencia Básica (2018-2019

  • CONACyT-México Grant: 536 (2016-2018) Convocatoria Fronteras en la Ciencia

  • CONACyT-México Grant: 229866 (2014-2014) Convocatoria Infraestructura

  • Grant CONACyT: 153583 (2010-2012)

  • Grant  VIEP- II 74101

  • Grant  CONACyT: F1-62610  (2006-2009)

  • Grant  CONACyT: J36062-N (2002-2005) 


IINVITED LECTURES
  • Broad-band tactile noise is most effective in improving motor performance and is most pleasant. Hand, Brain and Technology, Monte Verita Ascona, Switzerland  Conference organized by ETH Zurich, Switzerland, September 2014

  • Premovement potentials in the cat brainstem. University of Kazan (Volga Region) Federal University, Kremlim, Rusia December 2013.

  • Brainstem Reticular activating system for scratching and locomotion in the cat. University of Giessen, Germany November 2013.

  • Reticular activating system for a central pattern generator in the cat, Kirschtein Auditorium, National Institutes of Health, NIH, Bethesda, MD, USA, 11,11,2011

  • Neurodynamics of the center of mass for traveling electrical waves within the central nervous system of humans and cats, Max Planck Institute (MPIPKS) Dresden, Germany, 2007

  • Multisensory stochastic resonance in cats and humans, Universitat de les Illes Balears, Spain, 2005

  • Stochastic resonance in the spinal cord and somatosensory cortex of the cat, SPIE, Santa Fe, USA, 2003


PATENTS

IMPI (2012)


PUBLICATIONS

  1. Mendez-Balbuena I, Arrieta P, Huidobro N, Flores A, Lemuz-Lopez R, Trenado C, Manjarrez E (2018) Augmenting EEG-global-coherence with auditory and visual noise: Multisensory internal stochastic resonance. Medicine (Baltimore). 97(35): e12008. doi: 10.1097/MD.0000000000012008

  2. Cuellar CA, De La Torre Valdovinos B, Huidobro N, Delgado-Lezama R, Ornelas-Kobayashi R, Manjarrez E (2018) The Spinal Neurons Exhibit an ON-OFF and OFF-ON Firing Activity Around the Onset of Fictive Scratching Episodes in the Cat. Front Cell Neurosci. 12:68. doi: 10.3389/fncel.2018.00068

  3. Huidobro N, De la Torre-Valdovinos B, Mendez A, Treviño M, Arias-Carion O, Chavez F, Gutierrez R, Manjarrez E (2018) Optogenetic noise-photostimulation on the brain increases somatosensory spike firing responses. Neurosci Lett. 664: 51-57

  4. Canto-Bustos M, Loeza-Alcocer E, Cuellar CA, Osuna P, Elias-Viñas D, Granados-Soto V, Manjarrez E, Felix R, Delgado-Lezama R. (2017) Tonically Active ?5GABAA Receptors Reduce Motoneuron Excitability and Decrease the Monosynaptic Reflex. Front Cell Neurosci. 11:283

  5. Ceballos-Villegas ME, Saldaña-Mena JJ, Gutierrez-Lozano AL, Sepúlveda-Cañamar J, Huidobro N, Manjarrez E, Lomeli J. (2017) The complexity of H-wave amplitude fluctuations and their bilateral cross-covariance are modified according to the previous fitness history of young subjects under track training. Frontiers in human Neurosci. 11: 530

  6. Huidobro N, Mendez-Fernandez A, Mendez-Balbuena I, Gutierrez R, Kristeva R, Manjarrez E (2017) Brownian optogenetic-noise-photostimulation on the brain amplifies somatosensory-evoked field potentials. Front Neurosci. 11: 464. https://doi.org/10.3389/fnins.2017.00464

  7. Treviño M, De la Torre-Valdovinos B, Manjarrez E (2016) Noise improves visual motion discrimination via a stochastic resonance-like phenomenon. Front Hum Neurosci. 10: 572. http://dx.doi.org/10.3389/fnhum.2016.00572

  8. Flores A, Manilla S, Huidobro N, De la Torre-Valdovinos B, Kristeva R, Mendez-Balbuena I, Galindo F, Treviño M, Manjarrez E (2016) Stochastic resonance in the synaptic transmission between hair cells and vestibular afferents in development. Neuroscience. 322: 416-429.

  9. Franco LM, Beltrán JQ, Tapia JA, Ortiz F, Manjarrez E, Gutiérrez R (2016) Differential frequency-dependent antidromic resonance of the Schaffer collaterals and mossy fibers. Brain Struct Funct. 221(4):1793-1807  http://www.ncbi.nlm.nih.gov/pubmed/25665800

  10. Mendez-Balbuena I, Huidobro N, Silva M, Flores A, Trenado C, Quintanar L, Arias Carrion O, Kristeva R, Manjarrez E (2015) Effect of mechanical tactile noise on the amplitude of visual evoked potentials: Multisensory stochastic resonance. J Neurophysiol. In press

  11. Villafuerte G, Miguel-Puga A, Murillo-Rodriguez E, Machado S, Manjarrez E, Arias-Carrion O (2015) Sleep deprivation and oxidative stress in animal models: a systematic review. Oxidative Medicine and Cellular Longevity. 2015:234952. http://www.ncbi.nlm.nih.gov/pubmed/25945148

  12. Franco LM, Beltrán JQ, Tapia JA, Ortiz F, Manjarrez E, Gutiérrez R (2015) Differential frequency-dependent antidromic resonance of the Schaffer collaterals and mossy fibers. Brain Struct Funct. In press. Published online 11 Feb 2015. ISSN: 1863-2653.

  13. Trejo A, Tapia JA, De la Torre Valdovinos B, Huidobro N, Flores-Hernandez J, Flores A, Manjarrez E (2015) Transition of pattern generation: The phenomenon of post-scratching locomotion. Neuroscience. 288: 156-166

  14. Trenado C, Amtage F, Huethe F, Schulte-Monting J, Mendez-Balbuena I. Baker SN, Baker M, Hepp-Reymond MC, Manjarrez E, Kristeva R. Suppression of Enhanced Physiological Tremor via Stochastic Noise: Initial Observations. (2014) PlosOne 9(11): e112782. doi:10.1371/journal.pone.0112782

  15. Martinez-Silva L, Manjarrez E, Gutierrez-Ospina G, Quevedo JN. Electrophysiological representation of scratching CPG activity in the cerebellum. PlosOne 9(10): e109936. (2014) doi:10.1371/journal.pone.0109936

  16. Romero-Pimentel AL, Vazquez-Roque RA, Camacho-Abrego I, Hoffman KL, Linares P, Flores G, Manjarrez E. Histological correlates of N40 auditory evoked potentials in adult rats after neonatal ventral hippocampal lesión: animal model of schizophrenia. (2014) Schizophrenia Research. In Press.

  17. Herrera-May AL, Tapia JA, Dominguez-Nicolas SM, Juarez-Aguirre R, Gutierrez-D EA, Flores A, Figueras E, Manjarrez E Improved detection of magnetic signals by a MEMS sensor using stochastic resonance. PlosOne 9(10): e109534.(2014) doi:10.1371/journal.pone.0109534

  18. Trenado C, Mendez-Balbuena I, Manjarrez E, Huethe F, Schulte-Monting J, Feige B, Hepp-Reymond MC, Kristeva R (2014) Enhanced corticomuscular coherence by external stochastic noise. Front. Hum. Neurosci. doi: 10.3389/fnhum.2014.00325

  19. Cuellar CA, Trejo A, Linares P, Delgado-Lezama R, Jiménez-Estrada I, Abyazova LM, Baltina TV, Manjarrez E.(2014) Spinal neurons bursting in phase with fictive scratching are not related to spontaneous cord dorsum potentials. Neuroscience. 266C: 66-79

  20. Trenado C, Mikulic A, Manjarrez E, Mendez-Balbuena I, Schulte-Monting J, Huethe F, Hepp-Reymond MC, Kristeva R (2014) Broad-band Gaussian noise is most effective in improving motor performance and is most pleasant. Frontiers in Human Neuroscience. 8: 22.

  21. Juarez-Aguirre R, Dominguez-Nicolas SM, Manjarrez E, Tapia JA, Figueras E, Vazquez-Leal H, Aguilera-Cortes LA, Herrera-May AL (2013) Digital signal processing by virtual instrumentation of a MEMS magnetic field sensor for biomedical applications. Sensors 13:15068-15084.

  22. Tapia JA, Trejo A, Linares P, Alva JM, Kristeva R, Manjarrez E. Reticular activating system of a central pattern generator: premovement electrical potentials. Physiological Reports. 1 (5): 1-11, e00129, doi: 10.1002/phy2.129. (2013). A Journal from the American Physiological Society and the Physiological Society UK.  Wiley & Sons, Inc. All Rights Reserved

  23. Kato H, Cuellar CA, Delgado-Lezama R, Rudomin P, Jimenez-Estrada I, Manjarrez E, Mirasso CR . Modeling zero-lag synchronization of dorsal horn neurons during the traveling of electrical waves in the cat spinal cord. Physiol. Rep. 1(2): e00021., doi: 10.1002/phy2.21. ISSN 2051-817X. (2013) 1-14. A Journal from the American Physiological Society and the Physiological Society UK.  Wiley & Sons, Inc. All Rights Reserved

  24. Mendez-Balbuena I, Manjarrez E, Schulte-Mönting J, Huethe F, Tapia JA, Hepp-Reymond MC, Kristeva R, (2012) Improved sensorimotor performance via stochastic resonance.  Journal of Neuroscience. 32: 12612-12618.

  25. Mezzarane RA, Kohn AF, Couto E, Martinez L, Flores A, Manjarrez E (2012) Absence of effects of contralateral group I muscle afferents on presynaptic inhibition of Ia terminal in humans and cats. Journal of Neurophysiology. 108: 1176-1185.

  26. Mendez-Balbuena I, Huethe F, Schulte-Monting J, Leonhart R, Manjarrez E, Kristeva R (2012) Corticomuscular coherence reflects interindividual differences in the state of the corticomuscular networkduring low-level static and dynamic forces. Cerebral Cortex. 22: 628-638.  ISSN: 1047-3211

  27. Mezzarane RA, Kohn AF, Couto-Roldan E, Martinez L, Flores A, Manjarrez E (2012) Absence of effects of contralateral group I muscle afferents on presynaptic inhibition of Ia terminal in humans and cats. J Neurophysiol. In Press.

  28. Mendez-Balbuena I, Huethe F, Schulte-Monting J, Leonhart R, Manjarrez E, Kristeva R (2011) Corticomuscular coherence reflects interindividual differences in the state of the corticomuscular network during low-level static and dynamic forces. Cerebral Cortex.  ISSN: 1047-3211. In Press.   doi: 10.1093/cercor/bhr147

  29. Tapia JA, Herrera-May AL, Garcia-Ramirez PJ, Martinez-Castillo J, Figueras E, Flores A, Manjarrez E (2011) Sensing magnetic flux density of artificial neurons with a MEMS device. Biomedical Microdevices. 13: 303-313. ISSN: 1387-2176.

  30. Herrera-May AL, García-Ramírez PJ, Aguilera-Cortés LA, Plascencia-Mora H, Garcia-Gonzalez L, Manjarrez E, Narducci M, Figueras E (2011) Analytical Modeling for the Bending Resonant Frequency of Sensors Based on Micro-and Nanoresonators with Complex Structural Geometry. IEEE Sensors Journal. 11: 1361- 1374. ISSN: 1530-437X.

  31. Herrera-May AL, García-Ramírez PJ, Aguilera-Cortés LA,  Figueras E, Martinez-Castillo J, Manjarrez E, Sauceda A, Garcia-Gonzalez L, Juarez-Aguirre R. (2011) Mechanical design and characterization of a resonant magnetic field microsensor with linear response and high resolution. Sens Actuators A: Phys. 165: 399-409 ISSN: 0924-4247

  32. Tapia JA, Herrera-May AL, García-Ramírez PJ, Martinez-Castillo J, Figueras E, Flores A, Manjarrez E (2010) Sensing magnetic flux density of artificial neurons with a MEMS device. J Micromech microeng. SSN 0960-1317. En Prensa.

  33. Herrera-May AL, García-Ramírez PJ, Aguilera-Cortés LA, Plascencia-Mora H, Garcia-Gonzalez L, Manjarrez E, Narducci M, Figueras E (2010) Analytical Modeling for the Bending Resonant Frequency of Sensors Based on Micro-and Nanoresonators with Complex Structural Geometry. IEEE Sensors Journal. ISSN: 1530-437X. En Prensa.

  34. Herrera-May AL, García-Ramírez PJ, Aguilera-Cortés LA,  Figueras E, Martinez-Castillo J, Manjarrez E, Sauceda A, Garcia-Gonzalez L, Juarez-Aguirre R. (2010) Mechanical design and characterization of a resonant magnetic field microsensor with linear response and high resolution. Sens Actuators A: Phys.  ISSN: 0924-4247. En Prensa.

  35. Herrera-May A, Aguilera-Cortés A, Manjarrez E, González-Palacios M (2010) Nanoelectromechanical systems: origin, applications and challenges. Interciencia. 35 (3): 163-170. ISSN 0378-1844. Citado en ISI Web of Science; ISI Web of Knowledge.

  36. Herrera-May AL, Aguilera-Cortés LA, García-Ramírez PJ, Manjarrez E (2009) Resonant Magnetic Field Sensors Based On MEMS Technology.  SENSORS.  9: 7785-7813. ISSN 1424-822

  37. Perez T, Tapia JA., Mirasso CR, Garcia-Ojalvo J, Quevedo J, Cuellar CA, Manjarrez E. (2009) An intersegmental neuronal architecture for spinal wave propagation under deletions. Journal of Neuroscience. 29: 1054-10263. (Corresponding Author)

  38. Cuellar CA, Tapia JA, Juárez V, Quevedo J, Linares P, Martínez L, Manjarrez E (2009) Propagation of sinusoidal electrical waves along the spinal cord during a fictive motor task. Journal of Neuroscience, 29: 798-810. (Corresponding Author)

  39. Toscano-Márquez B, Martínez-Martínez E, Manjarrez E, Martínez L, Mendoza-Torreblanca J, Gutiérrez-Ospina G. (2008) Late onset muscle plasticity in the whisker pad of enucleated rats. PNAS, 105: 15973-15978. (Collaboration)

  40. Martínez L, Pérez T, Mirasso CR, Manjarrez E (2007) Stochastic resonance in the motor system: Effects of noise on the monosynaptic reflex pathway of the cat spinal cord. Journal of Neurophysiology, 97: 4007-4016. (Corresponding Author)

  41. Manjarrez E, Vazquez M, Flores A (2007) Computing the center of mass for traveling alpha waves in the human brain. Brain Research. 1145: 239-247. (Corresponding Author)

  42. Manjarrez E, Mendez I, Martinez L, Flores A, Mirasso CR (2007) Effects of auditory noise on the psychophysical detection of visual signals: Cross-modal stochastic resonance. Neuroscience Letters  415: 231-236. (Corresponding Author)

  43. Manjarrez E,  Balenzuela P, Garcia-Ojalvo J, Vasquez EE, Martinez L, Flores A,  Mirasso CR (2007) Phantom reflexes: Muscle contractions at a frequency not physically present in the input stimuli. Biosystems. 90: 379-388. (Corresponding Author)

  44. Balenzuela P, Garcia-Ojalvo J, Manjarrez E, Martínez L, Mirasso CR (2007) Ghost resonance in a pool of heterogeneous neurons. Biosystems.  89: 166-172. (Corresponding Author)

  45. Manjarrez E, Hernandez-Paxtian Z, Kohn AF (2005) A spinal source for the synchronous fluctuations of bilateral monosynaptic reflexes in cats. Journal of Neurophysiology. 94: 3199-210. (Corresponding Author)

  46. Zamora, C., Fraguela, A., Gómez, A., Cervantes, L.,  Manjarrez, E. (2005) Mathematical modeling and computer simulation of the Ia monosynaptic reflex fluctuations. Proceedings WSEAS Applied mathematics pp. 137-144.  ISBN: 960-8457-20-3. (Corresponding Author)

  47. Enriquez-Denton, M., Manjarrez, E., Rudomin, P. (2004) Persistence of PAD and presynaptic inhibition of muscle spindle afferents alter peripheral nerve crush. Brain Research 1027: 179-187.  (Collaboration)

  48. Manjarrez, E., Rojas-Piloni, J.G., Méndez,  Flores, A. (2003) Stochastic resonance within the somatosensory system: effects of noise on evoked field potentials elicited by tactile stimuli. Journal of Neuroscience 23: 1997-2001. (Corresponding Author)

  49. Manjarrez, E., Rojas-Piloni, G., Pérez, H., Méndez, I., Hernández-Paxtián, Z,  Flores, A. (2003) Stochastic resonance in the spinal cord and somatosensory cortex of the cat. Proceedings of SPIE. Paper Number 5110  pp. 102-113. (Corresponding Author)

  50. Manjarrez, E, Jiménez, I., Rudomin, P. (2003) Intersegmental synchronization of spontaneous activity of dorsal horn neurons in the cat spinal cord. Experimental Brain Research 148: 401-413. (Collaboration)

  51. Manjarrez, E., Perez, H., Rojas-Piloni, J.G., Vélez, D., Martínez, L., Flores, A. (2002) Absence of coherence between cervical and lumbar spinal cord dorsal surface potentials in the anaesthetized cat. Neuroscience Letters 328: 37-40. (Corresponding Author)

  52. Manjarrez, E., Rojas-Piloni, J.G., Méndez, I., Martínez, L., Vélez, D., Vázquez, D., Flores, A. (2002) Internal stochastic resonance in the coherence between spinal and cortical neuronal ensembles in the cat. Neuroscience Letters 326: 93-96 (Corresponding Author)

  53. Manjarrez, E., O. Diez-Martínez, I. Méndez, A. Flores. (2002) Stochastic resonance in human electroencephalographic activity elicited by mechanical tactile stimuli. Neuroscience Letters 324: 213-216.  (Corresponding Author)

  54. Manjarrez, E., Rojas-Piloni, G. Martínez, L., Vázquez, D., Vélez, D. Flores, A. (2002). Amplitude of somatosensory cortical evoked potentials correlated with spontaneous activity of spinal neurones in the cat. Neuroscience Letters 323: 187-190. (Corresponding Author)

  55. Manjarrez, E., Rojas-Piloni, G. Vazquez, D., Flores, A. (2002). Cortical neuronal ensembles driven by dorsal horn spinal neurones with spontaneous activity in the cat. Neuroscience Letters 318: 145-148. (Corresponding Author)

  56. Manjarrez, E., Rocha, T., Rojas-Piloni, J.G. Méndez, I.,  Flores, A. (2001). Nitric oxide modulates spontaneous cord dorsum potentials in the cat spinal cord. Neuroscience Letters 309(1): 5-8. (Corresponding Author)

  57. Manjarrez, E., Rocha, T., Rojas-Piloni, J.G. Méndez, I., Vélez, D., Flores, A. (2001). NO donor SIN-1 potentiates monosynaptic reflexes in the cat spinal cord. NeuroReport. 12(12): 2667-2671. (Corresponding Author)

  58. Manjarrez, E., Rojas-Piloni,  J.G., Jiménez, I.,  Rudomin, P.  (2000)   Modulation of synaptic transmission from segmental afferents by spontaneous activity of dorsal horn spinal neurones in the cat. Journal of Physiology (London) 529: 445-460. (PhD Thesis)

REVIEW OF MANUSCRIPTS FOR:
  • Journal of Neuroscience

  • Journal of Neurophysiology

  • Neuroscience Letters

  • Physical Review Letters


GRADUATE STUDENTS TRAINED

BCh Thesis: 20
MSci Thesis: 14
PhD Thesis: 6

Benemérita Universidad Autónoma de Puebla 4 sur 104 Centro Histórico C.P. 72000 Teléfono +52(222) 2295500
Instituto de Fisiología
14 sur 6301 Jardines de San Manuel
C.P. 72570
Teléfono +52(222) 2295500 ext. 7300, 7309 y 7310